The way forward for neuroethics in Japan: A review of five topics surrounding present challengesReview article Published on 2022-10-012022-10-05 Journal: Neuroscience Research [Category] 비임상, [키워드] Brain comparison Contact FIVE Human identity Impact intervene introduced Japan Japanese methodology Neuroethics non-human primates Perspective Psychiatric public health Research rule Support [DOI] 10.1016/j.neures.2022.07.006 [Article Type] Review article
Review of embryo-fetal developmental toxicity studies performed for pharmaceuticals approved by FDA in 2020 and 2021.Research article Published on 2022-09-012022-10-05 Journal: Reproductive toxicology (Elmsford, N.Y.) [Category] 비임상, [키워드] adopted adverse effect approvals approved clinician conducted developmental drug drugs FDA information majority monoclonal antibody non-human primate performed Pregnancy recommendation review risk rodent rule tested therapeutic Toxicity while [DOI] 10.1016/j.reprotox.2022.06.012 [Article Type] Research article
A Glance at the Development and Patent Literature of Tecovirimat: The First-in-Class Therapy for Emerging Monkeypox OutbreakArticle Published on 2022-08-252022-11-15 Journal: Viruses [Category] Fulltext, 원숭이두창, 진단, 치료제, [키워드] animal antivirals approved benefit Canada clinical study COVID-19 development disease dosage drug drug combination drug resistance Efficacy EMA European Medicines Agency food forms Health Canada highlight infections injection Interaction literature literature review Monkeypox MOST non-human primate off-label orthopoxvirus outbreak parameters Patent patents. pharmacokinetic regulatory agency rule SIGA-246 technology tecovirimat TPOXX treat Treatment United State USA Viral diseases website [DOI] 10.3390/v14091870 PMC 바로가기
Rule Extraction for Screening of COVID-19 Disease Using Granular Computing Approach세분화된 컴퓨팅 접근 방식을 사용한 COVID-19 질병 스크리닝을 위한 규칙 추출Article Published on 2022-06-222022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] 치료기술, [키워드] access to treatment affected appear approach Care collected computing congestion COVID-19 COVID-19 disease detect diagnosing disease early diagnosis Experimental result experimental results extraction feature granular health center initial symptom initial symptoms Patient problem Quality of service reduce reported rule Screening service Statistics Symptom Symptoms the epidemic training dataset Treatment variety virus [DOI] 10.1155/2022/8729749 PMC 바로가기 [Article Type] Article
Telemonitoring in Long-COVID Patients-Preliminary Findings장기 코로나 환자의 원격 모니터링 - 예비 결과Article Published on 2022-04-262022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 치료기술, [키워드] alleviate Analysis analyzed automatically average body temperature calculated cardiological cardiological and respiratory disorders caused condition cough COVID-19 pandemic detect Diagnosis diagnostic protocol diagnostics disorder disorders distance ECG electrocardiogram Engagement events examination exceeded finding flexibility Health Health status Healthcare system implementation indication life long-COVID machine learning parameter Patient problem professional provide provided pulse recognize recommendation required respiratory disorder respiratory disorders respiratory rate respond rule SARS-COV-2 infection saturation selected SPO Stress syndrome Telemedicine telemedicine. thresholds vital signs [DOI] 10.3390/ijerph19095268 PMC 바로가기 [Article Type] Article
Docking Analysis of Some Bioactive Compounds from Traditional Plants against SARS-CoV-2 Target ProteinsSARS-CoV-2 표적 단백질에 대한 전통적인 식물의 일부 생리 활성 화합물의 도킹 분석Article Published on 2022-04-202022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] Absorption binding affinity binding energy binding site bioactive compounds caffeic acid Cepharanthine Chimera Compound COVID-19 COVID-19 patients Curcumin cytochrome P450 Cytochrome P450 enzymes demonstrated docked drug-likeness exhibited Express expressed flavin global pandemic inhibited inhibiting inhibitor inhibitors inhibitory effect introduced Ligand ligands Medicine molecular molecular docking Multidrug resistance Papain Papain-like protease pharmacokinetic plant plants PLPro predicted prediction protease Protein protocol Quinine RdRP required Research Result RNA RNA dependent RNA polymerase RNA polymerase rule S-protein SARS-CoV-2 Spike protein suggested target target protein target proteins tested the disease theaflavin these compound these compounds Traditional traditional plants. treating COVID-19 patient Treatment viral spike protein Withaferin A [DOI] 10.3390/molecules27092662 PMC 바로가기 [Article Type] Article
The development of broad-spectrum antiviral medical countermeasures to treat viral hemorrhagic fevers caused by natural or weaponized virus infectionsReview Published on 2022-03-082022-10-28 Journal: PLoS Neglected Tropical Diseases [Category] COVID-19, [키워드] acute viral infection animal animal challenge studies anticipated Antiviral antiviral activity approval approved Biological breadth caused CFR Chemical clinical clinical benefit clinical development clinical evaluation clinical study conducted coronavirus 2 COVID-19 development disease drug drugs targeting Ebola Ebola virus Ebola virus disease Efficacy effort enzyme Evidence examined example facilitated FDA feasible Fever filoviruses food GS-5734 Hemorrhagic high-consequence pathogen highlight Hospitalization humans include Infection infectious agents inhibitor Laboratory testing Level 4 mechanism medical countermeasure NHP NHPs numbers of patient office outbreak outcome pandemic pathogen pathway Patient performed Prevent Program randomized clinical trials randomized, controlled trial RCTs Regulatory regulatory pathway Remdesivir Research respiratory RNA virus RNA-dependent RNA polymerase robust rule Safe SARS-CoV-2 severe disease Support therapeutic therapy treat Treatment Trial Vaccine viral infection viral pathogen viral replication virus virus virus infection while [DOI] 10.1371/journal.pntd.0010220 PMC 바로가기 [Article Type] Review
Public health emergency decision-making and management system sound research using rough set attribute reduction and blockchainArticle Published on 2022-03-042022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, SARS, [키워드] Accuracy analyzed applied approach attribute Characteristics Classifier cognitive COVID-19 dataset datasets decision Efficiency emergency response example extraction feasibility function health emergency IMPROVE investigated management measure mechanism musculoskeletal system occur Predictive markers preference Psychological Public public health emergency quantified reduce reduced reduction Research risk rule support vector machine SVM [DOI] 10.1038/s41598-022-07493-w PMC 바로가기 [Article Type] Article
Use of hiPSC-Derived Cardiomyocytes to Rule Out Proarrhythmic Effects of Drugs: The Case of Hydroxychloroquine in COVID-19Physiology Published on 2022-01-272022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] abnormality addition Asymptomatic Asymptomatic carrier baseline carrier Cohort Compound Concentration COVID-19 COVID-19 infection COVID-19 pandemic demonstrated drug Duration early phase ECG Effect Efficacy electrical field HCQ healthy healthy donors Hydroxychloroquine identify IMPROVE in vitro induced pluripotent stem cells inhibiting investigated Long Long QT syndrome Mutation Patient patients pharmacological interventions populations Potential Precision precision medicine Prognosis QT interval Replication rule safety pharmacology SARS-CoV-2 SARS-COV-2 infection silent susceptibility symptomatic symptomatic patient translational treat variant while [DOI] 10.3389/fphys.2021.730127 PMC 바로가기 [Article Type] Physiology
The effects of the COVID-19 pandemic on the use of the performance-enhancing drugsCOVID-19 전염병이 경기력 향상 약물 사용에 미치는 영향Article Published on 2022-01-192022-09-11 Journal: Acta bio-medica : Atenei Parmensis [Category] SARS, 치료기술, [키워드] activities activity addition addressed adopted adulteration adverse effect adverse effects Affect affected affecting anabolic Analysis androgenic steroid approach approach athletic Awareness blood sample business cause charge children closure Committee competing complex Compliance concerning Consumption Contamination Control coronavirus disease COVD-19 COVID-19 COVID-19 pandemic criteria damages Dilution doping Doping in sport driver driving drug Drug Abuse drugs Early detection Effect effort ENhance event events exacerbated forensic science foundation Government greater harmful substance Health Health Committee health protection impacted IMPROVE include increased risk information integrity introduced involved Italian Italy Laboratory lack list lockdown lockdowns measure methodology Modification MONITOR narcotic not limited NPs organization pandemic Patient phenomenon popularity positive Prescriptions Prevalence professional sports PROTECT protection provided public health raise raised raising Research revision risk rule Rule of law scaled Section similarity social distancing sports Spread Steroids Stress substance substance abuse Substance use Substance use disorder substance use disorders Substitution supervision suspicion tested the disease threat Threats Tokyo Transposition triggered Urine WADA World Anti-doping Agency [DOI] 10.23750/abm.v92i6.12377 PMC 바로가기 [Article Type] Article